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Flights from Detroit to South Carolina

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Flight deals from Detroit to South Carolina

Looking for cheap tickets from Detroit to South Carolina, or a last-minute trip? Find the lowest prices on one-way and return tickets right here.
Myrtle Beach.98 € per passenger.Departing Wed, 21 May, returning Sat, 24 May.Return flight with Spirit Airlines.Outbound direct flight with Spirit Airlines departs from Detroit Wayne County on Wed, 21 May, arriving in Myrtle Beach International .Inbound direct flight with Spirit Airlines departs from Myrtle Beach International on Sat, 24 May, arriving in Detroit Wayne County.Price includes taxes and charges.From 98 €, select.
Charleston.167 € per passenger.Departing Thu, 19 Jun, returning Sun, 22 Jun.Return flight with Spirit Airlines.Outbound direct flight with Spirit Airlines departs from Detroit Wayne County on Thu, 19 Jun, arriving in Charleston.Inbound direct flight with Spirit Airlines departs from Charleston on Sun, 22 Jun, arriving in Detroit Wayne County.Price includes taxes and charges.From 167 €, select.
Greenville.288 € per passenger.Departing Thu, 25 Sep, returning Mon, 29 Sep.Return flight with Southwest Airlines.Outbound indirect flight with Southwest Airlines, departs from Detroit Wayne County on Thu, 25 Sep, arriving in Greenville-Spartanburg.Inbound indirect flight with Southwest Airlines, departs from Greenville-Spartanburg on Mon, 29 Sep, arriving in Detroit Wayne County.Price includes taxes and charges.From 288 €, select.
Columbia.315 € per passenger.Departing Mon, 9 Jun, returning Tue, 17 Jun.Return flight with Delta.Outbound indirect flight with Delta, departs from Detroit Wayne County on Mon, 9 Jun, arriving in Columbia Metropolitan.Inbound indirect flight with Delta, departs from Columbia Metropolitan on Tue, 17 Jun, arriving in Detroit Wayne County.Price includes taxes and charges.From 315 €, select.
Florence.734 € per passenger.Departing Sun, 27 Apr, returning Mon, 28 Apr.Return flight with American Airlines.Outbound indirect flight with American Airlines, departs from Detroit Wayne County on Sun, 27 Apr, arriving in Florence.Inbound indirect flight with American Airlines, departs from Florence on Mon, 28 Apr, arriving in Detroit Wayne County.Price includes taxes and charges.From 734 €, select.

Flying from Detroit to South Carolina

Arm yourself with these facts on the fly.
Cheapest flight found98 €, Myrtle Beach
Cheapest month to flyMay
Average flight time1 hr, 56 mins
Cheapest airport to fly fromDetroit Wayne County
Most popular airlineDelta

Frequently asked questions

We looked at all of the upcoming return flights from Detroit to South Carolina we could find over the next 12 months. It looks like 98 € is the best price. This is good, compared to the average South Carolina ticket price of 318 €.
The cheapest month to fly from Detroit to Columbia Metropolitan Airport is usually June. The cheapest month to fly from Detroit to Florence Airport is usually April. The cheapest month to fly from Detroit to Myrtle Beach International Airport is usually May. And the cheapest month to fly from Detroit to Charleston Airport is usually June.
After crunching the numbers on our flight calendar, we found that it is currently cheapest to fly from Detroit to South Carolina on Wednesday, 21 May 2025.
Detroit Wayne County Airport offers direct flights to South Carolina.
If you're flying from Detroit, the cheapest city in South Carolina to fly into is Myrtle Beach. The cheapest airport serving Myrtle Beach at the moment is Myrtle Beach International .
The average flight time between Detroit and South Carolina is 1 hour and 56 minutes.